Intermittent ERR_CONNECTION_REFUSED issues

I am the network engineer for our company, and over the past month, we have had intermittent ERR_CONNECTION_REFUSED errors (on our wired connection, at times, when opening a new Chrome tab, we get the "Aw Snap", but after refreshing, it loads just fine). On wired, I experience this issue around 10 times/day. We also use an EHR application with tablets not provided by our company, but the vendor using an app they have developed. The way they have developed the app, is any time there is an "ERR_CONNECTION_REFUSED" error, the page "Oops", and the tablets have to be manually refreshed. The tablets are wireless on our production network. Previously, we had used our guest network (same AP, but a route map on our access switches going out a different circuit), and had the same issue. This has caused a lot of issues with patients and clinic staff's time as they have had to constantly refresh the tablets or hand out a different tablet. We have a Cisco environment, and have looked into our ASA to see if there are any logs in which there were none. We do not seem to have any browsing issues using a different browser, but these tablets were specifically designed to use Chrome. We have ruled out firepower, and we have not maxed out our translations (~23000 out of 65000). We use Meraki Access Points, and have not been able to find anything in the logs (other than 802.11 associations and disassociations, and DHCP information, I have not been able to see much in the event logs), but since it's happening on wired connections, I am beginning to rule out this is a wireless issue.
As another test, at a couple of sites, we have removed the tablets completely off our production network, and I enabled the 2.4 GHz band on our guest Comcast/Spectrum modems. Since that move, those specific tablets have not had any of the issues mentioned above. So the question, has anyone seen or experienced this issue? TIA for your advice and recommendations.