Can SDN be used in place of TRILL?

As I understand it, in a data center Clos / Leaf-Spine topology, you'll want to use TRILL at layer 2 (to avoid broadcast storms / loops without using STP, which would defeat the point of multipath forwarding)...

However, if you are using SDN in your data center, can a SDN control program handle that task instead of running the TRILL protocol?

I am interested both 1. in principle, is it possible - would it even work?, and 2. are real data centers out there actually doing this (or are they all still using TRILL or going to layer 3 to avoid the issue)?

Note: I'm aware that there are some TRILL alternatives out there. You may assume that when I say "TRILL" in this post, what I actually mean is "TRILL or TRILL-like protocol". ;)

Thanks!