PAC File influence application like Outlook Office 365?

Hi All,

We are using PAC file in our environment and Outlook O365 which the server name is configured using the address of https://mail.company.com/xxxx and I want to confirm the below.

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My question is regarding the forwarding of Outlook, Does it used the PAC file which includes the proxy server to connect to the cloud mail server https://mail.company.com/xxxx since it is bound to internet via https? If Yes, Is there any application or can we verify if pac file being used for outlook to reach the server? or this PAC file being used by the browser only and not by outlook application?

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Thank you